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Literature summary extracted from

  • Nagasaki, A.; Itoh, G.; Yumura, S.; Uyeda, T.Q.
    Novel myosin heavy chain kinase involved in disassembly of myosin II filaments and efficient cleavage in mitotic dictyostelium cells (2002), Mol. Biol. Cell, 13, 4333-4342.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.7 DNA sequence determination and analysis Dictyostelium discoideum

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.11.7 cell cortex
-
 Dictyostelium discoideum 5938
-
2.7.11.7 additional information MHCK A is localized to actin-rich regions in mitotic cells Dictyostelium discoideum
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.11.7 86000
-
 x * 86000, DNA sequence determination Dictyostelium discoideum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.7 ATP + myosin II heavy chain Dictyostelium discoideum
-
 ADP + myosin II heavy chain phosphate
-
 ?
2.7.11.7 ATP + myosin II heavy chain Dictyostelium discoideum involved in regulation of myosin II filament assembly ADP + myosin II heavy chain phosphate
-
 ?
2.7.11.7 ATP + myosin II heavy chain Dictyostelium discoideum AX2
-
 ADP + myosin II heavy chain phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.7 Dictyostelium discoideum
-
 gene MHCK A
-
2.7.11.7 Dictyostelium discoideum Q8MY12
-
-
2.7.11.7 Dictyostelium discoideum Q8MY12 myosin II heavy chain kinase C, gene mhckC
-
2.7.11.7 Dictyostelium discoideum AX2 Q8MY12
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.7 ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate catalytic domain: amino acid residues 31-259 Dictyostelium discoideum
a

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.7 ATP + myosin II heavy chain
-
 Dictyostelium discoideum ADP + myosin II heavy chain phosphate
-
 ?
2.7.11.7 ATP + myosin II heavy chain involved in regulation of myosin II filament assembly Dictyostelium discoideum ADP + myosin II heavy chain phosphate
-
 ?
2.7.11.7 ATP + myosin II heavy chain
-
 Dictyostelium discoideum AX2 ADP + myosin II heavy chain phosphate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.11.7 ?
-
 Dictyostelium discoideum
2.7.11.7 ? x * 86000, DNA sequence determination Dictyostelium discoideum

Synonyms

EC Number Synonyms Comment Organism
2.7.11.7 MHCK
-
 Dictyostelium discoideum

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.7 ATP
-
 Dictyostelium discoideum